Most Important Topics You Should Not Skip to Crack CSIR NET JRF Life Science Exam: Part 1

CSIR UGC NET JRF exam is most admired exam of India for lectureship, research and Ph.D in field of Life Science, Chemical Science, Physical Science and Earth Science. It enables the aspirants to enter India’s top research institutes and universities for PhD and Research.

Its hard shell to crack. It needs a very focused strategy and vision to crack CSIR NET Exam especially in Life Science. But you don’t have to worry..! Your own guide and a leader in CSIR NET Exam coaching platform, KapMan Academy, make a list of very important topics which is must prepared if you are a CSIR UGC NET JRF aspirant. At the end we also provide the list of reference books for preparation of this exam.

This is the list which covers most important topics and will help you out to crack CSIR UGC NET JRF exam as well other exams such as GATE, ICMR and DBT JRF.

Biochemistry

Attention and Yes a warning…! Do not think to skip this topic (aka Biochemistry) with fundamental processes if you are preparing for CSIR NET JRF Exam. It can lend you in a serious and troubled situation. It is like matching the dots to make a proper picture. This unit helps to make the connection with all other units. It will be difficult to understand the other units without understanding the biochemistry.

Most important subtopics in this unit are:

• Amino acids structure and functions. Pka value and isoelectric bonds

• Primary structure of proteins and nature of peptide bonds, Rmachandran plot, Protein sequencing

• Protein folding, denaturation, Enzymology, Enzyme kinetics., Do not forget to study the Enzymatic inhibition as well as Vmax, Km and inhibitor molecules.

• Metabolic pathways such as Glycolysis, Krebs cycle, Gluconeogenesis, ATP production, Enzymes involved in metabolic pathways and regulation of pathways.

• Enzyme category and group

• Lipid pathways and Lipid structure.

• Nucleic acid structure , DNA topology and dNTP as well as NTP synthesis

Cell Biology or Cellular organization

Cell Biology is an important unit for CSIR NET JRF Exam and it can carry about 20-25 marks. Mostly this unit is fact based and it would be better to make proper notes to avoid the forgetfulness which is mot common.

Important subtopics in this topic are:

• Membrane structure and function

• FRAP, RBC membrane,

• Lipids rafts, Freeze fracturing technique

• Membrane transport; All types of channels, pumps, transporter and its inhibitors.

• Membrane potential and neurotransmitter,

• Cytoskeleton and proteins involved in it such as kinesin, dynein, actin, myosin etc

• SER function, detoxification of drugs

• RER structure and function; protein synthesis in RER, Its packaging and transport to Golgi body , protein modification and enzymes involved in it.

• Lysosome, Lysosomal disorders, peroxisomes and glyoxisomes.

• Cell cycle, Different phases of cell cycle, its control and regulation. Its role in cancer and tumors.

• Cell division and mitosis.

• Meiosis I and Meiosis II

Fundamental Processes or Molecular Biology

Most important unit after biochemistry is Molecular biology for preparation of CSIR NET JRF Exam.

Important subtopics of this topic are:

• Initiation, elongation and termination of DNA replication, Full enzymatic machinery involved in this as well all protein factors.

• Types of DNA polymerases in prokaryotes and eukaryotes

• Initiation, elongation and termination of transcription, Full enzymatic machinery involved in this as well all protein factors.

• Types of RNA polymerase in eukaryotes. Structure of RNA polyemrase in prokaryotes.

• RNA splicing, Spliceosome complex, RNA Editing, mRNA maturation, tailing and capping of mRNA.

• Initiation , elongation and termination of translation, Full enzymatic machinery involved in this as well all protein factors, Ribosome structure and function.

• Post translation modification and proteosomes.

• Gene regulation in prokaryotes, Operon concept, Different types of operon and its regulation

• Gene regulation in eukaryotes; RNAi. RNA silencing, Histone modification and epigenetics.

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Reference books for Biochemistry

Lehninger Principles of Biochemistry 6th Edition, by Nelson and M.Cox

Biochemistry by Lubert Stryer

Reference books for Cell Biology

Cell and Molecular Biology by Gerald Karp

Molecular Cell Biology by Harvey Lodish

Reference books for Molecular biology

Molecular Biology of the Gene by James D. Watson

Lehninger Principles of Biochemistry by Nelson and M.Cox